Open AccessEffect of superoxide dismutase and catalase on spontaneously occurring chromosome breaks in patients with Fanconi's anemia
Author(s) -
NORDENSON I.
Publication year - 1977
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1977.tb01223.x
Subject(s) - catalase , superoxide dismutase , biology , chromosome , fanconi anemia , enzyme , chromatid , microbiology and biotechnology , genetics , biochemistry , dna , dna repair , gene
The effect of the two enzymes, superoxide dismutase (SOD) and catalase on spontaneously occurring chromosome breaks in 2 patients with Fanconi's anemia (FA) was studied. Cells, cultured in the presence of SOD and catalase, separately and combined, showed a significant decrease in the frequency of gaps and chromatid breaks ( P < 0.01). There was also a decrease in the frequency of chromosome aberrations in cells cultured in the presence of both SOD and catalase ( P <0.05). Since both enzymes are known to interfere with biological oxidation‐reduction processes, involving the production of different radicals, it is suggested that the decreased frequency of chromosome breaks is due to radical‐scavenging.