Open AccessIn vitro induction of G bands in human chromosomes
Author(s) -
RøNNE MOGENS
Publication year - 1977
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1977.tb00953.x
Subject(s) - biology , metaphase , in vitro , mitosis , dna , dna synthesis , rna , mitotic index , microbiology and biotechnology , genetics , biochemistry , biophysics , chromosome , gene
When added to cells in culture, daunomycin produces a marked decrease in mitotic index, an inhibition of the cellular synthesis of DNA, RNA and protein probably due to a binding of daunomycin to DNA. When added in low concentration to lymphoid cells in G 2 ‐phase, it also induces banding in the metaphase chromosomes. The bands are found to be G bands. The possible mechanism behind this in vitro induction is discussed.