Open AccessComparative studies of satellite association and some marker chromosomes in certified and suspected HeLa cells
Author(s) -
HANSSON ALF,
HENEEN WAHEEB K.
Publication year - 1976
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1976.tb01561.x
Subject(s) - hela , centromere , biology , satellite , genetics , normal group , human cell , cell , association (psychology) , cell culture , microbiology and biotechnology , chromosome , gene , endocrinology , physics , philosophy , epistemology , astronomy
The satellite association (SA) patterns were studied in five human cell lines: HeLa, Lu106, KB, HEp‐2 and D98/AH‐2. When some aspects of the phenomenon of SA were studied (mean number of SA complexes per cell and the proportion of the normal acrocentrics involved in SA in each cell), it became obvious that Lu106 and KB constituted one group and HEp‐2 and D98/AH‐2 another group. HeLa had some identities with both groups, but it was more similar to Lu106 and KB than to the other cell lines. The mean numbers and the standard errors of the different normal acrocentric chromosomes per cell were calculated. The standard errors of the acrocentrics were ranked in each cell line. The association tendencies of these chromosomes were ranked in the same manner. A high positive correlation between these aspects were found, which may indicate that a high SA tendency influences non‐disjunction. Some marker chromosomes were found in ‘association‐like’ configurations with normal acrocentrics. These associations were found most frequently with those markers which possibly include the short arm and other parts of normal acrocentric chromosomes. The results are in favour of a possible common origin of the five cell lines studied.