Open AccessSegregation of DNA in eukaryotic chromosomes
Author(s) -
SORSA VEIKKO
Publication year - 1976
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1976.tb01555.x
Subject(s) - biology , dna , dna replication , eukaryotic chromosome fine structure , genetics , chromosome , microbiology and biotechnology , computational biology , gene , telomere
A tentative model for explaining the mode of orientation and segregation of DNA in eukaryotic chromosomes has been proposed. The model is based on the interaction of several types of late replicating segments in chromosomal DNA. Particularly, the regulatory segments of transcriptional units are supposed to have an essential role in the orientation of DNA helices during and after the replication of chromomeric regions at S‐phase. By keeping together the old helices during the synthetic and condensation stages of chromosomal DNA, all the later replicating segments have a tendency to orientate and segregate the newly synthesized helices of DNA outwards after each duplication.