Open AccessChromosomal satellites as markers in human bone‐marrow transplantation
Author(s) -
Gahrton G.,
Zech L.,
Friberg K.,
Lundgren G.,
Möller E.,
Groth C.G.
Publication year - 1976
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1976.tb01191.x
Subject(s) - biology , transplantation , human leukocyte antigen , aplastic anemia , bone marrow , immunology , antigen , medicine
The use of chromosomal satellites as donor cell markers in human bone‐marrow transplantation is described. The recipient was a 17 year old boy with aplastic anemia, an HLA‐A, B, C and D as well as AB0 and Rh compatible brother served as the donor. No antigenic markers could be recognized. Donor cells had two distinct satellites on one of the chromosomes No. 21, while no such satellites were found in the recipient cells. After transplantation the recipient's bone marrow was replaced with cells containing the satellites, and the satellite marker was also found in PHA stimulated peripheral lymphocytes. This finding provided direct evidence of successful engraftment.