Open AccessInfluence of thyroid hormones on satellite association in man and the origin of chromosome abnormalities
Author(s) -
NILSSON CHRISTER,
HANSSON ALF,
NILSSON GÖRAN
Publication year - 1975
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1975.tb01514.x
Subject(s) - hormone , biology , thyroid , chromosomal translocation , thyroid hormones , endocrinology , medicine , nondisjunction , chromosome , physiology , genetics , aneuploidy , gene
The satellite association pattern was studied in cells from six hyperthyroid patients before and after antithyroid treatment. The same phenomenon was studied in cells from four healthy control individuals, without any history of thyroid dysfunction. The control cells were cultured in the following media: 1. medium with foetal calf serum and 2–3. media with serum from each of two patients with hyperthyroidism. All analyses were blind studies and were based on 1200 cells (50 cells in each individual sample). Chromosomes No. 21 and 14 (the latter to a lower extent) had a significantly higher association tendency, when the patients were hyperthyroid. The increase in association tendency of No. 21 and 14 was also found when cells from the control individuals were cultured in medium with serum from hyperthyroid patients. Also, chromosome No. 21 and 14 formed association pairs with each other more frequently when the cells were cultured in medium with excess of the thyroid hormones: thyroxin and triiodothyronin. It was concluded that these hormones increase the tendency to satellite association of chromosomes 21 and 14, and may therefore also increase the risk of nondisjunction and of translocation between these chromosomes.