Open AccessA prenatally discovered unbalanced translocation t(14;22) (q22 or 23;q13)
Author(s) -
WAHLSTRÖM JAN
Publication year - 1974
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1974.tb01446.x
Subject(s) - chromosomal translocation , biology , arthrogryposis , chromosome , genetics , prenatal diagnosis , miscarriage , fetus , pregnancy , gene
An unbalanced translocation between a chromosome in the 14th pair and a chromosome in the 22nd pair was discovered by a prenatal chromosome determination. The husband had the translocation in a balanced form. The wife had previously had one miscarriage, one still‐born child and a child which died after two months. The live‐born child had arthrogryposis. The possibility of the arthrogryposis being due to a chromosome aberration is discussed. The problems of prenatal genetic councelling are illustrated.