Open AccessNormal chiasma formation in a male with xeroderma pigmentosum
Author(s) -
HULTÉN MAJ,
WEERDKASTELEIN E. A.,
BOOTSMA D.,
SOLARI A. J.,
SKAKKEBAEK N. E.,
SWANBECK G.
Publication year - 1974
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1974.tb01434.x
Subject(s) - xeroderma pigmentosum , chiasma , biology , meiosis , genetics , dna , chromosomal crossover , ultraviolet light , chromosome , disease , dna repair , dermatology , gene , pathology , medicine , photochemistry , chemistry
A normal chiasma count was found in first spermatocytes from one patient with the classic symptoms of the genetic disease xeroderma pigmentosum (XP). Skin fibroblasts from this patient and from a brother affected with the same disease demonstrated a decreased ability to perform DNA repair synthesis, after ultraviolet light exposure. These findings indicate that the defective enzyme in XP, probably an incision enzyme, is not involved in the process of crossing‐over during meiosis.