Open AccessDifferent patterns of chromosome exchange induced by methyl‐metanesulphonate and mitomycin C in human cells
Author(s) -
BRØGGER A.
Publication year - 1974
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1974.tb00933.x
Subject(s) - mitomycin c , biology , chromosome , chromatin , dna , genetics , microbiology and biotechnology , gene
A comparison between 72 chromosome exchanges in human lymphocytes induced by methyl‐metanesulphonate (MMS) and 84 exchanges induced by mitomycin C (MC) revealed a different pattern. The prevalence of attenuations, lateral extensions and exchanges in the secondary constrictions of chromosomes 1, 9, and 16 in the MC‐treated material is not found with MMS. This may be due to a specific gathering effect of MC upon this particular chromatin. Both materials show a prevalence of C‐band exchange, which may be due to repetitious DNA.