Open AccessEvidence for an inverse relationship between X‐ray induced chromatid and chromosome breakage in human chromosomes
Author(s) -
JONASSON JON,
HOLMBERG MATS
Publication year - 1973
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1973.tb01167.x
Subject(s) - chromatid , breakage , biology , chromosome , genetics , irradiation , microbiology and biotechnology , physics , materials science , nuclear physics , gene , composite material
The distribution of chromatid‐breakage points along human chromosomes was studied in lymphocytes irradiated with X‐rays during the G 2 ‐period. The breakage points were found to be preferentially located in the R‐bands. This has also been shown for breakage points in exchange aberrations obtained after irradiation in the G 0 stage. However, chromosomes with relatively large amounts of R‐band material (showing a high frequency of exchange aberrations when irradiated during the G 0 stage) appeared to be underrepresented with regard to chromatid breakage points when irradiated during the G 2 stage and contrariwise. A possible mechanism that would account for this inverse relationship is discussed.