Open AccessDistribution of mitomycin C induced breaks on human chromosomes
Author(s) -
MORAD MOHAMED,
JONASSON JON,
LINDSTEN JAN
Publication year - 1973
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1973.tb01128.x
Subject(s) - mitomycin c , homologous chromosome , biology , chromatid , chromosome , genetics , microbiology and biotechnology , gene
Mitomycin C induced chromosome aberrations were analysed in cultured human lymphocytes by the quinacrine mustard chromosome banding technique. There was an overrepresentation of interchange aberrations involving the C‐bands of homologous chromosomes, and especially the secondary constrictions of chromosomes 1, 9 and 16. Interchanges involving other bands rarely occurred between homologous chromosomes. These findings indicate that the C‐bands are aggregated in the cell and/or that such an aggregation is induced by mitomycin C. The chromatid and chromosome breaks appeared to be located preferentially in the R‐bands.