Open AccessComparative chromosome analysis of primary and metastatic Rous sarcomas in rats
Author(s) -
MITELMAN FELIX
Publication year - 1972
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1972.tb00989.x
Subject(s) - biology , ploidy , chromosome , karyotype , rous sarcoma virus , cancer research , genetics , gene
The chromosomes were studied in 16 metastatic Rous (RSV—SR) rat sarcomas. About 40 % of the tumours had a normal diploid stemline and of these tumours about 70 % had 1 or 2 hyperdiploid sidelines. Among the heteroploid metastases, hyperdiploidy accounted for 2/3 and pseudodiploidy for 1/3 of the stemlines. The chromosome variation in the development of the heteroploid stem‐ and sidelines was non‐random and had the same characteristics as previously found in primary Rous rat sarcomas. There was a close karyotypic relation between the primary sarcomas and their metastases. The essential difference between them was an accelerated chromosomal progression in the secondary tumours. This progression was associated with a decrease in the histologic maturity of the tumours.