Open AccessA double dominant genetic mechanism for schizophrenia
Author(s) -
Karlsson Jón Löve
Publication year - 1970
Publication title -
hereditas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 50
eISSN - 1601-5223
pISSN - 0018-0661
DOI - 10.1111/j.1601-5223.1970.tb02324.x
Subject(s) - schizophrenia (object oriented programming) , mechanism (biology) , biology , psychosis , depressive symptoms , index case , transmission (telecommunications) , bipolar disorder , manic depressive psychosis , psychiatry , genetics , psychology , neuroscience , computer science , telecommunications , philosophy , cognition , epistemology , virology , outbreak
Family data from Iceland are reported, showing the rates of hospitalization with psychosis in different classes of relatives of index cases diagnosed schizophrenic, manic depressive, or psychotic depressive. The data are analyzed in terms of the probable mode of transmission for schizophrenia and are felt to fit best a mechanism requiring two separate dominant genes. Calculated rates for various relatives based on this model are compared to the empiric values.