Open AccessAssociation study in eating disorders: TPH2 associates with anorexia nervosa and self‐induced vomiting
Author(s) -
SlofOp ‘t Landt M. C. T.,
Meulenbelt I.,
Bartels M.,
Suchiman E.,
Middeldorp C. M.,
HouwingDuistermaat J. J.,
van Trier J.,
Onkenhout E. J.,
Vink J. M.,
van Beijsterveldt C. E. M.,
Brandys M. K.,
Sanders N.,
Zipfel S.,
Herzog W.,
HerpertzDahlmann B.,
Klampfl K.,
Fleischhaker C.,
Zeeck A.,
de Zwaan M.,
Herpertz S.,
Ehrlich S.,
van Elburg A. A.,
Adan R. A. H.,
Scherag S.,
Hinney A.,
Hebebrand J.,
Boomsma D. I.,
van Furth E. F.,
Slagboom P. E.
Publication year - 2011
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2010.00660.x
Subject(s) - tph2 , bulimia nervosa , anorexia nervosa , single nucleotide polymorphism , tryptophan hydroxylase , medicine , eating disorders , endocrinology , odds ratio , psychology , gastroenterology , serotonin , biology , psychiatry , genetics , receptor , genotype , serotonergic , gene
Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self‐induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71–91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D ( HTR1D ), tryptophan hydroxylase 2 ( TPH2 ) and brain‐derived neurotrophic factor ( BDNF ), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P ‐values < 0.05 from this initial study were then tested for replication in a meta‐analysis with two additional independent ED case–control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C‐allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08–1.57, P < 0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28–2.04, P < 0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16–1.64, P < 0.0003). The meta‐analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group.