Open AccessCognitive and non‐cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer’s disease
Author(s) -
Filali M.,
Lalonde R.,
Rivest S.
Publication year - 2009
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2008.00453.x
Subject(s) - irritability , apathy , psychology , cognition , disease , alzheimer's disease , neuroscience , depression (economics) , developmental psychology , medicine , economics , macroeconomics
Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non‐transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression‐like behavior in an Alzheimer’s disease model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left–right discrimination learning, concordant with previous findings in other Alzheimer‐like models.