Open AccessOf mice and men, periodic limb movements and iron: how the human genome informs the mouse genome
Author(s) -
Jones L. C.,
Earley C. J.,
Allen R. P.,
Jones B. C.
Publication year - 2008
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2008.00400.x
Subject(s) - restless legs syndrome , genome , homologous chromosome , gene , human genome , biology , limb development , genetics , neuroscience , neurology
The gene, BTBD9 , was recently linked to restless legs syndrome, periodic limb movements and iron status in humans. In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis. This finding is important as iron status in brain has been implicated in restless legs syndrome.