Open AccessEffects of sex chromosome aneuploidy on male sexual behavior
Author(s) -
Park J. H.,
BurnsCusato M.,
DominguezSalazar E.,
Riggan A.,
Shetty S.,
Arnold A. P.,
Rissman E. F.
Publication year - 2008
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2008.00397.x
Subject(s) - testis determining factor , y chromosome , biology , x chromosome , genetics , aneuploidy , chromosome , autosome , sex reversal , klinefelter syndrome , gene , endocrinology
Incidence of sex chromosome aneuploidy in men is as high as 1:500. The predominant conditions are an additional Y chromosome (47,XYY) or an additional X chromosome (47,XXY). Behavioral studies using animal models of these conditions are rare. To assess the role of sex chromosome aneuploidy on sexual behavior, we used mice with a spontaneous mutation on the Y chromosome in which the testis‐determining gene Sry is deleted (referred to as Y − ) and insertion of a Sry transgene on an autosome. Dams were aneuploid (XXY − ) and the sires had an inserted Sry transgene (XY Sry ). Litters contained six male genotypes, XY, XYY − , XX Sry , XXY − Sry , XY Sry and XYY − Sry . In order to eliminate possible differences in levels of testosterone, all of the subjects were castrated and received testosterone implants prior to tests for male sex behavior. Mice with an additional copy of the Y − chromosome (XYY − ) had shorter latencies to intromit and achieve ejaculations than XY males. In a comparison of the four genotypes bearing the Sry transgene, males with two copies of the X chromosome (XX Sry and XXY − Sry ) had longer latencies to mount and thrust than males with only one copy of the X chromosome (XY Sry and XYY − Sry ) and decreased frequencies of mounts and intromissions as compared with XY Sry males. The results implicate novel roles for sex chromosome genes in sexual behaviors.