Open AccessGenetic structure of hereditary catalepsy in mice
Author(s) -
Kulikov A. V.,
Bazovkina D. V.,
Kondaurova E. M.,
Popova N. K.
Publication year - 2008
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2008.00387.x
Subject(s) - catalepsy , congenic , backcrossing , biology , genetics , allele , gene , endocrinology , dopamine , haloperidol
Catalepsy or pronounced freezing is a natural passive defense strategy in animals and a syndrome of some mental disorders in human. Hereditary catalepsy was shown to be associated with depressive‐like features in rats and mice. The loci underlying the difference in predisposition to catalepsy between catalepsy‐prone CBA/lacJ and catalepsy‐resistant AKR/J mice were mapped using congenic line and selective breeding approaches. Three congenic mouse lines (AKR.CBA‐D13Mit76C, AKR.CBA‐D13Mit76A and AKR.CBA‐D13Mit78) carrying the 59‐ to 70‐, 61‐ to 70‐ and 71‐ to 75‐c m fragments of chromosome 13 transferred from the CBA to the AKR genome were created by nine successive backcrossing of (CBA × AKR)F 1 on AKR strain. Because catalepsy was found only in the AKR.CBA‐D13Mit76C and AKR.CBA‐D13Mit76A mice, the major gene of catalepsy was mapped on the fragment of 61–70 c m . Selective breeding of the (CBA × (CBA × AKR))BC backcross generation for high predisposition to catalepsy showed numerous genome‐wide distributed CBA‐derived alleles as well as the AKR‐derived alleles mapped on chromosome 17 and on the proximal parts of chromosomes 10 and 19 that increased the cataleptogenic effect of the major gene.