Open AccessMotor impairment in Alzheimer’s disease and transgenic Alzheimer’s disease mouse models
Author(s) -
Wirths O.,
Bayer T. A.
Publication year - 2008
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2007.00373.x
Subject(s) - genetically modified mouse , disease , phenotype , neuroscience , transgene , alzheimer's disease , amyloid precursor protein , medicine , biology , psychology , pathology , gene , genetics
In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer’s disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD‐associated genes like tau or amyloid precursor protein.