Open AccessLocalization of two new X‐linked quantitative trait loci controlling corpus callosum size in the mouse
Author(s) -
Kusek G. K.,
Wahlsten D.,
Herron B. J.,
Bolivar V. J.,
Flaherty L.
Publication year - 2007
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2006.00264.x
Subject(s) - corpus callosum , quantitative trait locus , biology , backcrossing , genetics , allele , phenotype , inbred strain , genetic linkage , chromosome , gene , anatomy
Corpus callosum (CC) size is a complex trait, characterized by a gradation of values within a normal range, as well as abnormalities that include a small or totally absent CC. Among inbred mouse strains with defects of the CC, BTBR T + tf /J (BTBR) mice have the most extreme phenotype; all animals show total absence of the CC and severe reduction of the hippocampal commissure (HC). In contrast, the BALB/cByJ (BALB) strain has a low frequency of small CC and consistently normal HC. Reciprocal F 1 crosses between BTBR and BALB suggest the presence of X‐linked quantitative trait loci (QTLs) affecting CC size. Through linkage analysis of backcross male progeny, we have localized two regions on the X chromosome, having peaks at 68.5 Mb (∼29.5 cM) and at 134.5 Mb (∼60.5 cM) that are largely responsible for the reciprocal differences, with the BTBR allele showing X‐linked dominant inheritance associated with CC defects.