Open AccessMitogen‐activated protein kinase/extracellular regulated kinase signalling and memory stabilization: a review
Author(s) -
Davis Sabrina,
Laroche Serge
Publication year - 2006
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2006.00230.x
Subject(s) - mapk/erk pathway , memory consolidation , mapk cascade , microbiology and biotechnology , protein kinase a , kinase , signalling , signal transduction , biology , neuroscience , mitogen activated protein kinase , hippocampus
The function of mitogen‐activated protein kinase (MAPK) in neurons has been the subject of considerable scrunity of late, and recent studies have given new insights into how this signalling cascade can regulate gene expression following cell‐surface receptor activation. At the same time, a wealth of experimental data has demonstrated that the MAPK cascade is critically involved in the mechanisms underlying the type of enduring modification of neural networks required for the stability of memories, emphasizing the high level of interest in this signalling molecule. In this review, we briefly outline the main molecular events and mechanisms of the regulation of the MAPK cascade leading to transcriptional activation and summarize recent advances in our understanding of the functional role of this molecular signalling cascade in regulating brain plasticity, memory consolidation and memory reconsolidation.