Open AccessGenes and neurons: molecular insights to fear and anxiety
Author(s) -
Stoppel C.,
Albrecht A.,
Pape H.C.,
Stork O.
Publication year - 2006
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2006.00229.x
Subject(s) - anxiety , psychology , neuroscience , cognitive science , psychiatry
Experimental animal models provide an important tool for the identification of inheritable components of fear and anxiety. ‘Pavlovian’ fear conditioning has been tremendously successful to characterize the neuronal circuitry and cellular mechanisms of the formation, consolidation and extinction of fear memories. Here we summarize recent progress that has led to the identification of gene products contributing to such experience‐dependent changes in fear and anxiety and may guide the search for genetic factors involved in the development and treatment of human anxiety disorders.