Open AccessThe genetic basis of circadian behavior
Author(s) -
Oster H.
Publication year - 2006
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2006.00226.x
Subject(s) - circadian rhythm , neuroscience , biology , suprachiasmatic nucleus , hypothalamus , endogeny , bacterial circadian rhythms , light effects on circadian rhythm , rhythm , circadian clock , endocrinology , medicine
In most species, an endogenous timing system synchronizes physiology and behavior to the rhythmic succession of day and night. The mammalian circadian pacemaker residing in the suprachiasmatic nuclei (SCN) of the hypothalamus controls peripheral clocks throughout the brain and the body via humoral and neuronal transmission. On the cellular level, these clockworks consist of a set of interwoven transcriptional/translational feedback loops. Recent work emphasizes the tissue specificity of some components of these molecular clockworks and the differential regulation of their rhythmicity by the SCN.