Open AccessCome FLY with us: toward understanding fragile X syndrome
Author(s) -
Zarnescu D. C.,
Shan G.,
Warren S. T.,
Jin P.
Publication year - 2005
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2005.00136.x
Subject(s) - fragile x syndrome , drosophila (subgenus) , fragile x , phenotype , identification (biology) , biology , on the fly , computational biology , drosophila melanogaster , genetics , evolutionary biology , computer science , gene , ecology , operating system
The past few years have seen an increased number of articles using Drosophila as a model system to study fragile X syndrome. Phenotypic analyses have demonstrated an array of neuronal and behavioral defects similar to the phenotypes reported in mouse models as well as human patients. The availability of both cellular and molecular tools along with the power of genetics makes the tiny fruit fly a premiere model in elucidating the molecular basis of fragile X syndrome. Here, we summarize the advances made in recent years in the characterization of fragile X Drosophila models and the identification of new molecular partners in neural development.