Open AccessTherapeutic implications of the mGluR theory of fragile X mental retardation
Author(s) -
Bear M. F.
Publication year - 2005
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2005.00135.x
Subject(s) - metabotropic glutamate receptor , anxiety , fragile x syndrome , metabotropic glutamate receptor 5 , neuroscience , glutamate receptor , fragile x , psychology , medicine , psychiatry , receptor , biology , genetics , gene
Evidence is reviewed that the consequences of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation are exaggerated in the absence of the fragile X mental retardation protein, likely reflecting altered dendritic protein synthesis. Abnormal mGluR signaling could be responsible for remarkably diverse psychiatric and neurological symptoms in fragile X syndrome, including delayed cognitive development, seizures, anxiety, movement disorders and obesity.