Open AccessA note on the effect of within‐strain sample sizes on QTL mapping in recombinant inbred strain studies
Author(s) -
Crusio W. E.
Publication year - 2004
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2004.00079.x
Subject(s) - inbred strain , strain (injury) , quantitative trait locus , heritability , recombinant dna , biology , correlation , genetics , phenotype , genetic correlation , trait , genetic variation , gene , mathematics , computer science , geometry , anatomy , programming language
This note explores the effect of within‐strain sample sizes on the correlations between a phenotype and a molecular‐genetic marker in a battery of inbred strains. It is shown that the maximum correlation possible between a molecular marker and a behavioral or neuronal phenotype equals the additive‐genetic correlation. How close the strain correlation will approach the additive‐genetic correlation depends only on heritability and within‐strain sample sizes. The equations derived can be used to optimize designs of studies attempting to localize Quantitative Trait Loci utilizing Recombinant Inbred Strains, provided information about the heritability of the character under study is available.