Open AccessDNA variants in the human RAB3A gene are not associated with autism
Author(s) -
D'Adamo P.,
Bacchelli E.,
Blasi F.,
Lipp H.P.,
Toniolo D.,
Maestrini E.
Publication year - 2004
Publication title -
genes, brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 91
eISSN - 1601-183X
pISSN - 1601-1848
DOI - 10.1111/j.1601-183x.2003.00058.x
Subject(s) - autism , gene , genetics , dna , mutation , knockout mouse , biology , gene knockout , psychology , psychiatry
Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. Since Rab3a constitutive knockout mice react to novel stimuli with hyperactivity, a further search for association of RAB3A DNA variants with other neurobehavioral disorders such as attention deficit/hyperactivity disorder appears justified.