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The oral‐systemic personalized medicine model at Marshfield Clinic
Author(s) -
Glurich I,
Acharya A,
Shukla SK,
Nycz GR,
Brilliant MH
Publication year - 2013
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2012.01921.x
Subject(s) - personalized medicine , medicine , oral medicine , informatics , precision medicine , intervention (counseling) , health informatics , medline , alternative medicine , intensive care medicine , bioinformatics , pathology , public health , nursing , dentistry , political science , law , electrical engineering , biology , engineering
Oral Diseases (2012) 19 , 1–17 Periodontal disease and diabetes, two diseases that have achieved epidemic status, share a bidirectional relationship driven by micro‐inflammatory processes. The present review frames the current understanding of the pathological processes that appear to link these diseases and advances the hypothesis that reversal of the epidemic is possible through application of interdisciplinary intervention and advancement of oral‐systemic personalized medicine. An overview of how Marshfield Clinic’s unique clinical, informatics and bio‐repository resources and infrastructures are being aligned to advance oral‐systemic personalized medicine is presented as an interventional model with the potential to reverse the epidemic trends seen for these two chronic diseases over the past several decades. The overall vision is to engineer a transformational shift in paradigm from ‘personalized medicine’ to ‘personalized health’.