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A preliminary study on the FAM5C expression in generalized chronic periodontitis
Author(s) -
Ribeiro FV,
Santos VR,
Bastos MF,
de Miranda TS,
Vieira AR,
de Figueiredo LC,
Duarte PM
Publication year - 2012
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2011.01855.x
Subject(s) - chronic periodontitis , rankl , periodontitis , osteoprotegerin , medicine , tumor necrosis factor alpha , receptor , interleukin 17 , immunology , activator (genetics) , inflammation
Oral Diseases (2012) 18 , 147–152 Objective: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers. Material and Methods: Gingival biopsies were harvested from periodontally healthy subjects (n = 10) and chronic periodontitis subjects (n = 15). The levels of mRNA of FAM5C, interleukin (IL)‐17, IL‐6, IL‐23, IL‐10, IL‐4, interferon‐γ, toll‐like receptor (TLR)‐2, TLR‐4, osteoprotegerin (OPG), receptor activator of NF‐ κ B ligand (RANKL), tumor necrosis factor (TNF)‐α, transforming growth factor‐β, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real‐time polymerase chain reaction. Results: FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P > 0.05). Gene expressions of IL‐17, TNF‐α, OPG, RANKL, TLR‐2, and TLR‐4 were higher in periodontitis, when compared to periodontally healthy sites (P < 0.05), while no differences between groups were observed for the other genes evaluated (P > 0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers ( P > 0.05). Conclusion: Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis.