Premium
MCP‐1 and CCR2 gene variants in oral squamous cell carcinoma
Author(s) -
BektasKayhan K,
Unur M,
BoyMetin Z,
Cakmakoglu B
Publication year - 2012
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2011.01843.x
Subject(s) - genotype , allele , ccr2 , haplotype , basal cell , restriction fragment length polymorphism , polymerase chain reaction , allele frequency , gene , medicine , biology , gastroenterology , genetics , receptor , chemokine receptor , chemokine
Oral Diseases (2011) 18 , 55–59 Aim: We aimed to investigate a possible association of the MCP‐1 and CCR2 polymorphisms with the risk of developing oral squamous cell carcinoma (OSCC). Methods: MCP‐1 A2518G and CCR2 V64I gene polymorphisms were performed by polymerase chain reaction and restriction fragment length polymorphism, in 129 patients with OSCC and 140 healthy control subjects. Results: Individuals who had G allele and GG genotype of MCP‐1, and 64I allele and wt/64I genotype of CCR2 had increased risk for OSCC (P < 0.05.) In contrast, individuals with CCR2 wt/wt genotype seem to be protected from OSCC ( P < 0.01). Haplotype analysis revealed that MCP‐1G: CCR2 64I haplotype frequencies were significantly higher in patients than those of controls (P = 0.001). Conclusions: We can suggest that the G allele of MCP‐1 and 64I allele of CCR2 may be risk factors for OSCC.