Premium
New thoughts on the initiation of mucositis
Author(s) -
Sonis ST
Publication year - 2010
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2010.01681.x
Subject(s) - mucositis , regimen , medicine , psychological intervention , pathogenesis , stage (stratigraphy) , intensive care medicine , bioinformatics , toxicity , biology , psychiatry , paleontology
Oral Diseases (2010) 16 , 597–600 It has been slightly more than a decade since the classic mechanistic paradigm that defined the pathogenesis of mucositis was revised. A five‐stage sequence of linked biological events forms the basis for our current understanding of how regimen‐related mucosal injury occurs. The first stage is the initiation phase, although the gateway to toxicity has been the least studied. This essay proposes new thoughts on the phase’s components, how they might interact, and how they present new opportunities for treatment interventions and mucositis risk prediction.