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Unexpected roles for bone marrow stromal cells (or MSCs): a real promise for cellular, but not replacement, therapy
Author(s) -
Mezey É,
Mayer B,
Németh K
Publication year - 2010
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2009.01605.x
Subject(s) - mesenchymal stem cell , stromal cell , stem cell , clinical uses of mesenchymal stem cells , regenerative medicine , bone marrow , embryonic stem cell , adult stem cell , medicine , cell therapy , stem cell transplantation for articular cartilage repair , immune system , cancer research , immunology , biology , pathology , microbiology and biotechnology , biochemistry , gene
Oral Diseases (2010) 16 , 129–135 Adult and embryonic stem cells have drawn a lot of attention in the last decade as new tools in regenerative medicine. A variety of such cells have been discovered and put forward as candidates for use in cell replacement therapy. Investigators hope that some, if not all, of our organs can be replaced or restored to function; that new livers, kidneys, and brain cells can be produced. Many reviews have already been written about stem cells and their potential use in regenerating tissues. In this study, we would like to call attention to a different application of a special group of adult stem cells, the stromal cells in the bone marrow (also called mesenchymal stem cells or MSCs). These cells have been discovered to modulate immune function. They can easily be expanded in culture and surprisingly, they also seem not to be immunogenic. Thus, they can be removed from donors, expanded, stored in freezers, and used as allogeneic transplants in a variety of diseases in everyday medicine.