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Influence of ovariectomy and masticatory hypofunction on mandibular bone remodeling
Author(s) -
Patullo IMF,
Takayama L,
Patullo RF,
Jorgetti V,
Pereira RMR
Publication year - 2009
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2009.01599.x
Subject(s) - medicine , bone mineral , masticatory force , condyle , ovariectomized rat , mandible (arthropod mouthpart) , femur , estrogen , soft tissue , endocrinology , bone density , osteoporosis , dentistry , anatomy , biology , surgery , botany , genus
This study was designed to examine the effect of masticatory hypofunction and estrogen deficiency on mandible bone mass and compare this site with spine and femoral bone. Methods: Twenty‐four rats were ovariectomized (OVX) or Sham‐operated (Sham) and analyzed after feeding with hard diet (Hard) or soft diet (Soft). They were divided into four groups: (GI)Sham‐Hard; (GII)OVX‐Hard; (GIII)Sham‐Soft and (GIV)OVX‐Soft. Bone mineral density (BMD) was measured in the spine and femur in the baseline and at the end of the study, and ΔBMD (final BMD − baseline BMD) was calculated. In mandible bone, BMD and histomorphometry were analyzed at the end of the experiment. Results: Sham rats showed higher spine (GI: 13.5% vs GII: 0.74%, P < 0.01; GIII: 10.67% vs GIV: −4.36%, P < 0.001) and femur ΔBMD (GI: 14.43% vs GII: 4.42%, P < 0.01; GIII: 10.58% vs GIV: 0.49%, P < 0.001) than OVX, but no difference was observed in mandible BMD among these groups ( P > 0.05). Soft‐diet groups showed decreased mandible BMD compared with hard‐diet groups (GIV vs GII, P < 0.01; GIII vs GI, P < 0.01). Similarly, mandibular condyle histomorphometry showed that soft‐diet groups presented a significant decrease in trabecular thickness and volume (GIV vs GII, P < 0.05; GIII vs GI, P < 0.01) compared with hard diet. Conclusion: Our results suggest that mandibular bone loss resulted from decreased of mechanical loading during mastication, and was not affect by estrogen depletion.