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Oxidant/antioxidant status in recurrent aphthous stomatitis
Author(s) -
Arikan S,
Durusoy C,
Akalin N,
Haberal A,
Seckin D
Publication year - 2009
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2009.01580.x
Subject(s) - recurrent aphthous stomatitis , malondialdehyde , lipid peroxidation , glutathione peroxidase , oxidative stress , medicine , pathogenesis , vitamin e , gastroenterology , stomatitis , antioxidant , selenium , glutathione , immunology , chemistry , superoxide dismutase , biochemistry , enzyme , organic chemistry
Objective: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae, and oxidative stress presumably contributes to its pathogenesis. The study was performed to evaluate the involvement of oxidant toxicity in this disorder. Methods: Patients with RAS ( n = 26) and age‐ and sex‐matched healthy control subjects ( n = 20) were included in this study. Following an overnight fast, blood specimens were obtained. Plasma malondialdehyde concentrations and erythrocytes glutathione peroxidase activities were determined. Also, plasma vitamin E and selenium levels were detected. Mann–Whitney U ‐test was performed for statistical evaluation. Results: Oxidative stress was confirmed by the significant elevation in plasma malondialdehyde levels and by the significant decrease in glutathione peroxidase activities, vitamin E and selenium levels ( P < 0.001). Conclusions: Our results indicated that lipid peroxidation and the inadequacy of the defense system seem to play a crucial role in the pathogenesis of recurrent aphthous stomatitis.