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Immunoexpression of MMPs‐1, ‐2, and ‐9 in ameloblastoma and odontogenic adenomatoid tumor
Author(s) -
Ribeiro BF,
Iglesias DPP,
Nascimento GJF,
Galvão HC,
Medeiros AMC,
Freitas RA
Publication year - 2009
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2009.01575.x
Subject(s) - ameloblastoma , adenomatoid odontogenic tumor , pathology , matrix metalloproteinase , stromal cell , parenchyma , immunohistochemistry , medicine , stroma , molar , dentistry
Objective: The aim of this study was to evaluate and compare the expression of metalloproteinases‐1, ‐2, and ‐9 in solid ameloblastoma and adenomatoid odontogenic tumor. Methods: A total of 20 cases of solid ameloblastoma and 10 cases of adenomatoid odontogenic tumors were selected and immunohistochemically assessed. Metalloproteinases‐1, ‐2, and ‐9 immunoexpression and their distribution pattern were noted and semiquantitatively scored. The scores obtained were statistically analyzed. Results: Matrix metalloproteinase (MMP)‐1 showed a predominant expression in both tumors and was found in stroma and parenchyma. For MMP‐2, there was a varied expression, with 80% and 60% of immunoreactive tumor cells in ameloblastoma and adenomatoid odontogenic tumor respectively. Regarding stromal cells, 65% of ameloblastomas and 80% of adenomatoid odontogenic tumors showed positivity. There was immunoexpression of the MMP‐9 in parenchymal and stromal cells in all cases of both tumors analyzed. A statistically significant difference in the expression of MMP‐1 in relation to the expression of MMP‐2 and ‐9 in ameloblastomas ( P < 0.001) was observed. Conclusion: The results suggest that these metalloproteinases are related to growth and progression of tumors analyzed, and particularly in ameloblastoma, its highest aggressiveness may be, in part, a result of the active participation of the stromal cells and their products, such as the MMPs studied.