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Serum sCD14, polymorphism of CD14 −260 and periodontal infection
Author(s) -
Raunio T,
Knuuttila M,
Karttunen R,
Vainio O,
Tervonen T
Publication year - 2009
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2009.01573.x
Subject(s) - medicine , cd14 , microbiology and biotechnology , immunology , biology , immune system
Background and Aims: CD14 is a co‐receptor involved in the recognition of Gram‐negative and positive bacteria. Infections are known to influence serum sCD14 levels, and CD14 gene promoter polymorphism (CD14 C−260T) has been reported to be associated with many infectious diseases. Our aim was to investigate whether serum sCD14 concentration is associated with periodontal infection and the CD14 −260 genotype. Subjects and Methods: The periodontal status of 56 subjects with chronic periodontitis and 28 controls was clinically examined. Serum sCD14 concentration was analyzed using ELISA and CD14 −260 genotype using polymerase chain reaction (PCR). Results: The mean concentration of sCD14 in serum was significantly higher in subjects with periodontitis than in control subjects (4.9 μ g ml −1 vs 3.8 μ g ml −1 , P < 0.001). Serum sCD14 concentration associated significantly with the extent of advanced periodontal disease. In a regression analysis including both subject groups, the CD14 −260 genotype was a significant determinant for serum sCD14 concentration. After stratification by periodontal health status (periodontitis vs controls), the influence of the CD14 −260 genotype on serum sCD14 concentration was seen only in the control group. Conclusions: Periodontal infection is associated with the serum concentration of sCD14. Moderate to severe periodontal infection overshadows the influence of the genotype on serum sCD14 concentration.