Premium
Relation of bone turnover markers to periodontal disease and jaw bone morphology in elderly Japanese subjects
Author(s) -
Yoshihara A,
Deguchi T,
Hanada N,
Miyazaki H
Publication year - 2009
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2008.01511.x
Subject(s) - deoxypyridinoline , bone remodeling , medicine , bone resorption , osteocalcin , dentistry , resorption , endocrinology , cortical bone , bone disease , alkaline phosphatase , pathology , osteoporosis , biology , biochemistry , enzyme
Objective: The purpose of this study was to evaluate the relation of bone turnover markers such as bone formation and resorption to periodontal disease and jaw bone morphology in elderly Japanese subjects. Subjects and methods: We selected 148 subjects for participation in this study. All subjects were aged 77 years. The periodontal examination included the assessment of clinical attachment level (CAL). Biochemical parameters of bone turnover measured included urinary deoxypyridinoline, serum osteocalcin (S‐OC), and serum bone‐specific alkaline phosphatase. In addition, to evaluate the jawbone, we used the mandibular inferior cortex classification (MIC). Results: Serum osteocalcin had significantly higher (males: P = 0.038, females: P = 0.041) tendency for MIC Class (ANOVA). Multiple linear regression results showed that the number of remaining teeth and S‐OC were negatively associated with the percentage of sites with ≥6 mm CAL ( R 2 = 0.322, P < 0.001). Coefficients and betas were −0.71, −0.46 ( P < 0.001) and −1.11, −0.28 ( P = 0.002), respectively. Conclusion: In conclusion, this study suggests that there is a significant relation of bone turnover markers to periodontal disease and jaw bone morphology in elderly Japanese subjects.