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Oral diseases associated with hepatitis C virus infection. Part 1. sialadenitis and salivary glands lymphoma
Author(s) -
Carrozzo M
Publication year - 2008
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2007.01436.x
Subject(s) - sialadenitis , hepatitis c virus , medicine , lymphoma , cryoglobulinemia , salivary gland , immunology , virus , hepatitis c , disease , pathology
Morbidity associated with hepatitis C virus (HCV) infection is due not only to the sequelae of chronic liver disease, but also to a variety of extraheaptic manifestations (EHM). Some of the most frequently reported EHM of HCV infection involves the oral region predominantly or exclusively and they are the topics of this 2‐part review. The current part 1 discusses the evidences on the association of salivary glands disorders with HCV. HCV‐ infected patients may frequently have histological signs of Sjögren‐like sialadenitis with mild or even absent clinical symptoms. However, the pathogenetic role of HCV in Sjogren Syndrome (SS) development and the characteristics distinguishing classic SS from HCV‐related sialadenitis are still an issue. It is unclear if the virus may cause a disease mimicking primary SS or if HCV is directly responsible for the development of SS in a specific subset of patients. Notably, some patients may present a triple association between HCV, SS‐like sialadenitis and salivary gland lymphoma and the virus may be involved in the lymphomagenesis. The risk of having a salivary gland lymphoma is particularly high in patients with mixed cryoglobulinemia. Little attention has been paid to the effects of anti‐HCV treatment on sialadenitis or lymphoma development.