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Regenerative approaches in the craniofacial region: manipulating cellular progenitors for oro‐facial repair
Author(s) -
Buxton PG,
Cobourne MT
Publication year - 2007
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2007.01403.x
Subject(s) - craniofacial , regeneration (biology) , regenerative medicine , distraction osteogenesis , skull , progenitor cell , neuroscience , stem cell , anatomy , biology , medicine , distraction , microbiology and biotechnology , genetics
This review aims to highlight the potential for regeneration that resides within the bony tissues of the craniofacial region. We examine the five main cues which determine osteogenic differentiation: heritage of the cell, mechanical cues, the influence of the matrix, growth factor stimulation and cell‐to‐cell contact. We review how successful clinical procedures, such as guided tissue regeneration and distraction osteogenesis exploit this resident ability. We explore the developmental origins of the flat bones of the skull to see how such programmes of differentiation may inform new therapies or regenerative techniques. Finally we compare and contrast existing approaches of hard tissue reconstruction with future approaches inspired by the regenerative medicine philosophy, with particular emphasis on the potential for using chondrocyte‐inspired factors and replaceable scaffolds.