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Usefulness of mouse models to study the pathogenesis of Sjögren's syndrome
Author(s) -
Soyfoo MS,
Steinfeld S,
Delporte C
Publication year - 2007
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2007.01376.x
Subject(s) - pathogenesis , autoimmune disease , medicine , disease , pathophysiology , immunology , sjögren syndrome , systemic disease , immunopathology , dermatology , pathology
Sjögren's syndrome (SS) is an autoimmune disorder characterized by ocular and oral dryness as well as systemic manifestations. The immunopathogenesis of SS is complex with different intricate factors. Because of the delay in the appearance of symptoms and due to ethical issues it is very difficult to study the wide array of factors intervening in the pathogenesis of SS in human patients. To circumvent this problem, different animal models have been elaborated for studying the different subsets of the aspects of the physiopathology of this disease. In this review, we focus on the mouse models that have been established to deepen our insight into the immunopathogenesis of SS.