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Vaccine‐based approaches to squamous cell carcinoma of the head and neck
Author(s) -
Zhang X,
Moche JA,
Farber D,
Strome SE
Publication year - 2007
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2006.01329.x
Subject(s) - medicine , head and neck , head and neck squamous cell carcinoma , basal cell , oncology , head and neck cancer , intensive care medicine , surgery , radiation therapy
Vaccine‐based approaches for the treatment of advanced squamous cell carcinoma of the head and neck have achieved very limited success. Improvement in vaccine efficacy for both diseases control and survival is predicated on a careful analysis of the root causes for successes and failures to date. In this review, we analyse the utility and limitations of select protective and therapeutic vaccine strategies for tumour prevention and therapy. Based on this characterisation, we define potential directions which are meritorious of future study.