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Bone marrow‐derived mesenchymal stem cells for regenerative medicine in craniofacial region
Author(s) -
Miura M,
Miura Y,
Sonoyama W,
Yamaza T,
Gronthos S,
Shi S
Publication year - 2006
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2006.01300.x
Subject(s) - craniofacial , stem cell , mesenchymal stem cell , regenerative medicine , pathology , medicine , bone marrow , stem cell transplantation for articular cartilage repair , regeneration (biology) , clinical uses of mesenchymal stem cells , cartilage , anatomy , biology , adult stem cell , cellular differentiation , microbiology and biotechnology , biochemistry , psychiatry , gene
The craniofacial region contains many specified tissues including bone, cartilage, muscle, blood vessels and neurons. Defect or dysfunction of the craniofacial tissue after post‐cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly expected. Bone marrow‐derived mesenchymal stem cells (BMMSCs) are one of the most well characterized postnatal stem cell populations, and considered to be utilized for cell‐based clinical therapies. Here, the current understanding and the potential applications in craniofacial tissue regeneration of BMMSCs are reviewed, and the current limitations and drawbacks are also discussed.