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The homeobox HOXB13 is expressed in human minor salivary gland
Author(s) -
Cazal C,
Sobral APV,
De Almeida FCS,
Das Graças SilvaValenzuela M,
Durazzo MD,
Nunes FD
Publication year - 2006
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2005.01218.x
Subject(s) - homeobox , serous fluid , biology , in situ hybridization , cdx2 , morphogenesis , carcinogenesis , salivary gland , pathology , gene , gene expression , medicine , genetics , biochemistry
Background: Homeobox are a family of developmental genes involved in morphogenesis and cellular differentiation. Participation of homeobox within normal and malignant tissue has been recently discussed in the literature. Objective: To analyze the presence of HOXB13 transcript expression in human minor salivary gland. Material and methods: Ten‐micrometer sections from frozen samples were evaluated employing non‐radioactive in situ hybridization technique and HOXB13 mRNA probes. Results: HOXB13 was found to be expressed in ducts and mucous acini but not in serous acini. Conclusions: Results suggest that HOXB13 transcripts are differently expressed in normal mucous and serous acini, and it may possibly reflect a different role in salivary gland carcinogenesis.