Premium
Effects of alendronate and hormone replacement therapy, alone and in combination, on saliva, periodontal conditions and gingival crevicular fluid matrix metalloproteinase‐8 levels in women with osteoporosis
Author(s) -
Eviö S,
Tarkkila L,
Sorsa T,
Furuholm J,
Välimäki MJ,
Ylikorkala O,
Tiitinen A,
Meurman JH
Publication year - 2006
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2005.01186.x
Subject(s) - medicine , osteoporosis , dentistry , saliva , norethisterone acetate , hormone replacement therapy (female to male) , femoral neck , menopause , bone mineral , bleeding on probing , alendronic acid , periodontitis , testosterone (patch)
Objective: To compare the effects of hormone replacement therapy (HRT), alendronate and their combination on oral health of elderly postmenopausal women with osteoporosis. Materials and methods: Sixty patients, aged 65–80 years (mean 71 years), with a T‐score of bone mineral density of −2.5 s.d. or less at either the lumbar spine or the femoral neck, were randomized to receive 2 mg of estradiol plus 1 mg norethisterone acetate (HRT) ( n = 20), 10 mg of alendronate ( n = 18), or their combination ( n = 22) for 2 years. Periodontal and oral status and mouth symptoms were recorded, and salivary analyses made at the beginning and at the end of the study. Gingival crevicular fluid (GCF) matrix metalloproteinase (MMP‐8) levels were determined to address destructive events in periodontal tissue. Results: Resting salivary flow rate decreased by 19% ( P < 0.05), and GCF MMP‐8 tended to increase in the alendronate group. None of the regimens affected subjective feelings of dry or burning mouth. There were no significant changes in dental or periodontal status, stimulated flow rate or composition of saliva during the study. Conclusions: Alendronate decreased resting salivary flow rate but otherwise HRT or alendronate separately or in combination had no effect on oral health in elderly women with osteoporosis.