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Mandible analysis in sex steroid‐deficient rats
Author(s) -
Armada L,
Nogueira CRR,
Neves UL,
Santos Souza P,
Detogne JP,
ArmadaDias L,
Moreira RM,
NascimentoSaba CCA
Publication year - 2006
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2005.01184.x
Subject(s) - ovariectomized rat , dental alveolus , periodontal fiber , mandible (arthropod mouthpart) , castration , bone remodeling , resorption , bone resorption , medicine , sex steroid , endocrinology , estrogen , osteoporosis , sexual dimorphism , hormone , dentistry , steroid , biology , botany , genus
The aim of this study was to evaluate, by morphologic techniques, the effects of sex steroid deficiency on mandible bone remodeling of female rats, in groups of different experimental periods and to compare the results with 90‐day orquiectomized males. Female and male Wistar rats, 3 months old, were divided into experimental groups and at the end of each experimental period were killed, and mandibles were extracted. The left mandibles were prepared with rote technique bone and examined by a light microscope. Morphological analyses of the mandibles demonstrated resorption signals in the alveolar bone, after 30 days in ovariectomized females, but it was more intense 90 days after castration. The orquiectomized group exhibited some signals of resorption similar to the ovariectomized group of 60 days. Morphometric analysis of alveolar bone thickness in females after 60 days was in agreement with morphological results. However, the analysis of periodontal ligament thickness did not show any significant difference. There were variations in sexual hormone deficiency in the mandibles of males and females and they seemed to be more precocious in ovariectomized than in orquiectomized rats. It is important for a health professional to have knowledge about bone metabolism to improve the quality of life of postmenopaused and old people.