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In vitro antifungal effect of amine fluoride‐stannous fluoride combination on oral Candida species
Author(s) -
Meurman JH,
Kari K,
Waltimo T,
Kotiranta A,
Inkeri J,
Samaranayake LP
Publication year - 2006
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2005.01156.x
Subject(s) - candida dubliniensis , candida krusei , corpus albicans , microbiology and biotechnology , candida tropicalis , candida parapsilosis , candida albicans , candida glabrata , yeast , fluoride , antifungal , chemistry , biology , biochemistry , inorganic chemistry
Objective: The combination of amine fluoride and stannous fluoride (AmF/SnF 2 ) was, by chance, found to be antifungal in a clinical trial. This study investigated its effect on pathogenic Candida species with the hypothesis that the antifungal action on different species is variable. Materials and methods: Growth inhibition effect of Meridol ® mouth rinse which contains 250 ppm AmF/SnF 2 was evaluated on 43 reference and clinical strains of Candida albicans , C. dubliniensis , C. glabrata , C. guilliermondii , C. krusei , C. parapsilosis , and C. tropicalis . Meridol ® base solution without AmF/SnF 2 was used as a negative control. Results: Undiluted Meridol ® mouth rinse killed most study strains within a few minutes. In ascending order, C. parapsilosis , C. tropicalis , C. albicans , C. glabrata , C. krusei and C. dubliniensis showed higher resistance against AmF/SnF 2 than C. guilliermondii . Conclusion: AmF/SnF 2 could be used as a potent adjunct to antifungal therapy for oral yeasts. Although different Candida species demonstrated variable sensitivity the most prevalent oral yeast C. albicans appeared sensitive to the AmF/SnF 2 combination.