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Clinical efficacy of a triclosan/copolymer/NaF dentifrice and a commercially available breath‐freshening dentifrice on hydrogen sulfide‐forming bacteria
Author(s) -
Vazquez J,
Pilch S,
Williams M,
Cummins D
Publication year - 2005
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2005.01105_45.x
Subject(s) - dentifrice , saliva , dentistry , medicine , triclosan , fluoride , oral hygiene , chemistry , inorganic chemistry , pathology
Objective The objective of this double blind clinical study was to compare the 4‐h and overnight effects of a triclosan/copolymer/fluoride (TCF) dentifrice and a commercially available breath freshening (CBF) dentifrice containing fluoride for their ability to control H 2 S‐forming bacteria. Methods Following a one‐week washout period of brushing with a regular fluoride dentifrice, subjects reported to the clinical site without performing oral hygiene, eating or drinking in preparation for baseline saliva sampling. After providing a baseline saliva sample, subjects were randomly assigned a test dentifrice and instructed to brush their teeth for one minute, twice a day for one week. On the morning of the 8th day, subjects returned to the test site having refrained from oral hygiene, eating and drinking for overnight sampling. Subjects then brushed for 1 min with the assigned dentifrice, and returned for 2‐ and 4‐h postbrushing evaluations. Following a second one‐week washout, subjects repeated the same regimen, but now using the other dentifrice. Oral micro‐flora samples were collected by subjects rinsing with 10 ml of sterile water for 10 s. Each collected sample was serially diluted and plated in duplicate onto lead acetate agar. After incubating for 72 h, dark colonies were counted, expressed as log colony‐forming units ml −1 , and reductions from baseline were calculated. Results Compared to baseline, the TCF dentifrice reduced H 2 S‐forming bacteria 0.82, 0.80 and 0.22 log units at the 2‐, 4‐ and 12‐h time points compared to 0.60, 0.43 and 0.07 log units for the CBF dentifrice. The TCF dentifrice was statistically significantly better ( P < 0.05) than the CBF dentifrice at 4 h and overnight after brushing the teeth. Conclusion These results support data obtained in organoleptic and gas chromatography studies and strongly suggest that the TCF dentifrice is effective in controlling bacteria implicated in the formation of bad breath.