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Alterations in expression of retinoid receptor β and p53 in oral submucous fibrosis
Author(s) -
Kaur J,
Chakravarti N,
Mathur M,
Srivastava A,
Ralhan R
Publication year - 2004
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.2004.00993.x
Subject(s) - pathogenesis , oral submucous fibrosis , carcinogenesis , retinoid , immunohistochemistry , pathology , malignancy , medicine , fibrosis , retinoic acid receptor , retinoic acid , cancer research , cancer , biology , gene , genetics
Objective: Knowledge of the molecular pathogenesis of oral submucous fibrosis (OSF), a potentially malignant condition with high risk of transition to oral cancer, is meagre. Alterations in the expression of retinoic acid receptor β (RAR β ) and tumor suppressor gene, p53 are early events in oral tumorigenesis. The aim of this study was to investigate the alterations in the expression of RAR β and p53 in OSF lesions and determine their association with disease pathogenesis. Methods: The expression of RAR β and p53 proteins was analyzed by immunohistochemistry in 50 cases of OSF and 30 histologically normal oral tissues. Results: No detectable RAR β expression was observed in 35 of 50 (70%) OSF cases. p53 protein accumulation was observed in 24 of 50 (48%) OSF cases analyzed. Thirty‐six percent OSF lesions showed loss of RAR β and p53 overexpression. Interestingly, 41 of 50 (82%) of OSF lesions showed altered expression of at least one of these two proteins. Conclusion: Altered expression of either RAR β or p53 in majority of OSF lesions suggests their association with disease pathogenesis and warrants follow‐up to determine whether OSF lesions harboring concomitant alterations in RAR β and p53 are at a high risk of transition to malignancy.