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Prostaglandin E 2 levels in blood plasma and in crevicular fluid of advanced periodontitis patients before and after surgical therapy
Author(s) -
Leibur E,
Tuhkanen A,
Pintson Ü,
Söder PÖ
Publication year - 1999
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.1999.tb00305.x
Subject(s) - medicine , pathogenesis , venous blood , prostaglandin e2 , radioimmunoassay , prostaglandin e , periodontitis , gastroenterology , bleeding on probing
AIM: The aim of the study was to determine PGE 2 levels in venous blood plasma (VBP), gingival blood plasma (GBP) and gingival crevicular fluid (GCF) in advanced periodontal patients before and after 6 months surgical treatment. PATIENTS AND METHODS: There were 12 patients aged 28–45 years and seven healthy subjects as controls included into the study. Clinical parameters such as PLI, GI, BI, PD, AL and bone height % from radiographs were recorded before and after treatment. PGE 2 levels were determined by radioimmunoassay (125 I RIA Kit, NEN®). RESULTS: Before treatment the mean VBP, GBP and GCF PGE 2 levels in periodontal patients were higher than healthy controls ( P < 0.001, Student's t ‐test). Six months after treatment the mean levels of PGE 2 in VBP, GBP and GCF were significantly reduced in patients with improvement of clinical and roentgenological parameters ( P < 0.001, Student's t ‐test). CONCLUSIONS: It can be concluded that PGE 2 is involved in the pathogenesis of periodontal disease. The inflamed periodontal tissues may produce significant amount of PGE 2 and the degree of inflammation might be determined by the ratios of PGE 2 . The lower levels of PGE 2 in blood plasma and in gingival crevicular fluid after treatment are signs of improvement of periodontal disease.