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Severe oral ulceration in patients with HIV infection: A case series
Author(s) -
Zakrzewska JM,
Robinson P,
Williams IG
Publication year - 1997
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/j.1601-0825.1997.tb00359.x
Subject(s) - medicine , asymptomatic , etiology , thalidomide , retrospective cohort study , dermatology , human immunodeficiency virus (hiv) , disease , surgery , multiple myeloma , family medicine
OBJECTIVE: Oral ulceration occurs in an estimated 2–4% of patients with HIV infection. This retrospective observational study describes the aetiology and characteristics of 94 HIV‐positive patients with either severe and/or recurrent oral ulceration presenting at a dedicated HIV dental unit over a 4‐year period. METHODS: Case records were reviewed for diagnosis investigations, CD4 count, CDC stage and treatment modality. RESULTS: Of the 94 patients 50% had an AIDS diagnosis. In patients with asymptomatic HIV disease minor recurrent oral ulceration was the commonest diagnosis whilst large non‐specific neutropenic ulcers were more frequently seen in patients with symptomatic disease with low CD4 counts. A variety of treatment modalities were used including thalidomide. An algorithm is presented for the management of patients with severe oral ulceration.